The predictive role of NF-κB-mediated pro-inflammatory cytokine expression levels in hepatitis B vaccine responseArticle Published on 2023-03-042023-06-13 Journal: Journal of immunoassay & immunochemistry [Category] B형 간염, [키워드] hepatitis B NF‑kB pro-inflammatory cytokines systemic inflammation Vaccine response. [DOI] 10.1080/15321819.2022.2164507 PMC 바로가기
Activation of Early Proinflammatory Responses by TBEV NS1 Varies between the Strains of Various SubtypesArticle Published on 2023-01-052023-06-22 Journal: International Journal of Molecular Sciences [Category] 조류인플루엔자, [키워드] nonstructural protein 1 (NS1) pro-inflammatory cytokines tick-borne encephalitis virus (TBEV). [DOI] 10.3390/ijms24021011 PMC 바로가기
Nitazoxanide and COVID-19: A reviewArticle Published on 2022-11-012022-11-15 Journal: Molecular biology reports [Category] SARS, 치료제, [키워드] Activation acute lung injury acute respiratory distress acute respiratory distress syndrome addition Anti-inflammatory anti-parasitic drug anti-SARS-CoV-2 Antiviral antiviral activity antiviral property ARDS autophagic cause cell death clinical trial Coronavirus disease 2019 COVID-19 Cytokine storm Cytokines distress drug effective finding IFN immunological in silico in vitro study Infection inflammatory disorders inflammatory reaction inhibit Innate immunity interferon lung mammalian mitigate Multi-organ damage nitazoxanide oxidative stress pathogenesis of SARS-CoV-2 pro-inflammatory cytokines pro-inflammatory cytokines. Prospective Study Protozoa Rapamycin reduce Respiratory Coronavirus SARS-CoV-2 SARS-CoV-2 infections severe cases syndrome therapy Treatment triggered viral infections Viral pneumonia [DOI] 10.1007/s11033-022-07822-2 PMC 바로가기
Small-molecule screening identifies Syk kinase inhibition and rutaecarpine as modulators of macrophage training and SARS-CoV-2 infectionArticle Published on 2022-10-042022-11-16 Journal: Cell Reports [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome chromosomal Compound coronavirus Coronavirus infection CP: Immunology Effect Effects highlighting human macrophages identify induce influenza A inhibit inhibitor innate immune innate immune training LPS LPS tolerance Macrophage memory modulate modulation Necrosis NFAT-2 OC43 pro-inflammatory cytokine pro-inflammatory cytokines promote promoter prophylactic treatment reported rutaecarpine. SARS-CoV-2 SARS-COV-2 infection secretion small molecule susceptibility Syk inhibition TNF Tolerance Topology variant [DOI] 10.1016/j.celrep.2022.111441 PMC 바로가기
Ursolic acid and SARS-CoV-2 infection: a new horizon and perspectiveArticle Published on 2022-10-012022-11-15 Journal: Inflammopharmacology [Category] COVID19(2023년), SARS, 치료제, [키워드] acute lung injury acute respiratory distress acute respiratory syndrome Anti-inflammatory anti-inflammatory cytokines antioxidant antioxidant effects Antiviral ARDS Complication complications coronavirus COVID-19 Cytokine storm disease-causing disorders dysregulation hyper inflammation immune response Immunity IMPROVE indirect effect inflammatory signaling inhibit lung manifestation mitigate neurological oxidative stress pandemic pandemics. Pathways Perspective pro-inflammatory cytokine pro-inflammatory cytokines progression RAS reactive oxygen specy reduce renin-angiotensin system ROS SARS-CoV-2 SARS-COV-2 infection severe cases syndrome ursolic acid Viral pneumonia [DOI] 10.1007/s10787-022-01038-3 PMC 바로가기
SARS-CoV-2 infects adipose tissue in a fat depot- and viral lineage-dependent mannerArticle Published on 2022-09-292022-11-15 Journal: Nature Communications [Category] SARS, 변종, 진단, [키워드] ACE2 adipose Adiposity anatomical Cell cell death cells cellular response Disease progression Express expression fat fat cell infect Infection Lineage occur pro-inflammatory cytokines risk factor SARS-CoV-2 SARS-COV-2 infection severe COVID-19 susceptibility susceptible the SARS-CoV-2 tissue variant viability visceral [DOI] 10.1038/s41467-022-33218-8 PMC 바로가기
SARS-CoV-2 Nsp14 protein associates with IMPDH2 and activates NF-κB signalingArticle Published on 2022-09-132022-11-16 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, [키워드] activate Activation acute respiratory syndrome bortezomib caused contribute coronavirus COVID-19 patients cytokine Host identify IL-6 IL-8 IMPDH2 Infection inhibitor Interaction knockdown lung tissue sample mechanism mycophenolic acid NF-κB NF-κB activation NF-κB signaling nsp14 nuclear translocation occurred p65 pro-inflammatory cytokines promote Protein proteomic regulate ribavirin ribavirin. SARS-CoV-2 SARS-CoV-2 infected cells SARS-COV-2 infection the SARS-CoV-2 upregulation viral infection viral replication [DOI] 10.3389/fimmu.2022.1007089 PMC 바로가기
Mesenchymal stem cell treatment for hyperactive immune response in patients with COVID-19COVID-19 환자의 과민성 면역 반응을 위한 중간엽 줄기세포 치료Review Published on 2022-09-012022-09-11 Journal: Immunotherapy [Category] COVID19(2023년), SARS, 변종, [키워드] Biomarker Biomarkers clinical clinical immunology clinical trials COVID-19 COVID-19 mortality COVID-19 patients CRP Cytokines decrease Effect effective Endothelitis epithelial cells Human immune system IL-6 immune response immune system independent invasive mesenchymal stem cell Mesenchymal stem cells mesenchymal stem cells. MSC MSC therapy MSCs organism patients with COVID-19 potential treatment option pro-inflammatory cytokine pro-inflammatory cytokines PROTECT reduction in regenerative regimen reported Respiratory failure Safe sick stem cell stem cells systemic systemic effects therapy Treatment Trial [DOI] 10.2217/imt-2021-0245 PMC 바로가기 [Article Type] Review
Acquisition of Furin Cleavage Site and Further SARS-CoV-2 Evolution Change the Mechanisms of Viral Entry, Infection Spread, and Cell Signaling푸린 절단 부위의 획득 및 추가 SARS-CoV-2 진화는 바이러스 진입, 감염 확산 및 세포 신호 전달의 메커니즘을 변경합니다Article Published on 2022-08-102022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 acquisition activate activating Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response alphavirus appear cathepsin Cathepsins Cell Cell fusion change coronavirus COVID COVID-19 disease Cytokines Deletion determined by endosome Entry mechanism entry pathway Evolution experimental system expressing S protein expression FCS furin furin cleavage furin cleavage site hallmark human population immune in vitro induce infected with SARS-CoV-2 infecting Infection inhibitor inhibitors lack leads Lineage mAbs mechanism media mRNA vaccines Neutralizing neutralizing monoclonal antibodies neutralizing monoclonal antibody pro-inflammatory cytokines pro-inflammatory response pseudoinfectious viruses pseudovirus pseudoviruses receptor released respiratory S protein S1 secretion S1 subunit SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 S protein secrete sera severe acute respiratory syndrome Coronavirus shown Site Spike protein Spread spreading Syncytia syncytium syncytium formation the S protein the S1 subunit TLR4 TMPRSS2 TMPRSS2 expression variant Viral viral evolution viral evolution. virus virus entry virus spread [DOI] 10.1128/jvi.00753-22 PMC 바로가기 [Article Type] Article
Interleukin 6: A biomarker for COVID-19 progressionResearch article Published on 2022-08-022022-10-05 Journal: Sensors (Basel, Switzerland) [Category] 바이오마커, 신약개발, 임상, 치료제, [키워드] “cytokine storm” Biomarker caused China clinical trial Concentration COVID COVID-19 COVID-19 progression CRS cytokine Cytokine release syndrome Cytokine storm Diagnosis disease Health highlight IL-6 IL-6 level immune system immunoregulation Infection Inflammation inhibited interleukin interleukin-6 massive inflammatory monoclonal antibodies monoclonal antibody morbidity and mortality multi-organ dysfunction pandemic Patient pleiotropic pro-inflammatory cytokines progression receptor reduce reducing Respiratory failure resulting SARS-CoV-2 serum severe complications severity of COVID-19 significantly therapeutic target through contact transmitted Treatment World Health Organization zoonotic [DOI] 10.1016/j.matpr.2022.07.387 [Article Type] Research article